Drug cocktails for effective treatment of glioblastoma multiforme.

نویسنده

  • Waldemar Debinski
چکیده

Waldemar Debinski, MD, PhD Director of Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Forest University, Departments of Neurosurgery, Radiation Oncology, & Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA Tel.: +1 336 716 9712 Fax: +1 336 713 7639 [email protected] “Just about everything that relates to glioblastoma multiforme pathobiology and its clinical course invites thinking about specific targeting of more than one tumor compartment/target and more than one mechanism controlling the pathobiology...”

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Glioblastoma Multiforme in Children, A Case-Report

ABSTRACT: Glioblastoma multiforme is the most malignant primary brain tumor .It usually occurs in the 5th and 6th decades of life and is rare in childern. In this paper a case of glioblastoma multiforme is reported in a ten year - old child who presented with two week's history of headache with no neurological defect.C.T scan revealed å right frontal mass with massive surrounding oedema. He w...

متن کامل

Natural Bioactive Compounds: Alternative Approach to the Treatment of Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most frequent, primary malignant brain tumor prevalent in humans. GBM characteristically exhibits aggressive cell proliferation and rapid invasion of normal brain tissue resulting in poor patient prognosis. The current standard of care of surgical resection followed by radiotherapy and chemotherapy with temozolomide is not very effective. The inefficacy of t...

متن کامل

Radiothermotherapy for glioblastoma multiforme: A preliminary study

Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods:   In this study, 38 GBM patients were included. 19 patients were treated ...

متن کامل

Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.

Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells. Analysis of gene expression databases revealed that CypB is upregu...

متن کامل

Evaluation of doses in the Wernicke and Broca’s areas using two different technique in patients with right frontal glioblastoma multiforme

Background: Broca’s and Wernicke’s areas, which are important language areas of brain, are commonly irradiated in patients with right frontal lobe glioblastomamultiforme (GBM). We aimed to compare two different treatment planning techniques in terms of the doses in the Broca’s and Wernicke’s areas for the patients with right frontal GBM. Materials and Methods: Two differ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Expert review of neurotherapeutics

دوره 8 4  شماره 

صفحات  -

تاریخ انتشار 2008